New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.
نویسندگان
چکیده
New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole.
منابع مشابه
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry
دوره 20 16 شماره
صفحات -
تاریخ انتشار 2012